The risk of CVD mortality in type two diabetic patients is over double compared with that in age-matched subjects. Stroke events and every one manifestations of CHD, myocardial infarct (MI), sudden death, and heart disease is at least twofold additional common in patients with type two diabetes than in non-diabetic people. A high proportion of patients with type 2 diabetes die after an acute MI within 1 year, and a considerable number of patients die outside the hospital. Relative risk for CHD events is higher in female patients with type two polygenic disease than in male patients with type two polygenic disease. The reason for the sex difference is largely unknown however may be a minimum of partially explained by a heavier risk-factor burden and a greater effect of blood pressure and atherogenic dyslipidemia on the chance of CVD in diabetic ladies than in diabetic men.
The prognosis of patients with type two diabetes is extremely keen about the presence of CVD. We compared the 7-year incidence of fatal and nonfatal MI among 1,373 non-diabetic subjects with the incidence among 1,059 subjects with type 2 diabetes. Our study advised that patients with type two diabetes without previous MI have as high a risk of MI as non-diabetic patients with previous MI. Thus, our results indicated that type 2 diabetes is a “coronary heart disease equivalent.” These results were recently replicated by an 18-year follow-up study of our original cohort and by a Danish study including 3.3 million subjects. One of the paradoxes within the studies of cardiovascular complications in type two polygenic diseases is that at diagnosing people with type two diabetes already has considerably increased prevalence of CHD and stroke.
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